Comparative dissolution testing of paracetamol commercial tablet dosage forms

Özkan Y., Özalp Y., Savaşer A., ÖZKAN S. A.

Acta Poloniae Pharmaceutica - Drug Research, cilt.57, sa.1, ss.33-41, 2000 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 1
  • Basım Tarihi: 2000
  • Dergi Adı: Acta Poloniae Pharmaceutica - Drug Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.33-41
  • Anahtar Kelimeler: Basket apparatus, In vitro availability, Paddle apparatus, Paracetamol, Physical controls
  • Ankara Üniversitesi Adresli: Evet

Özet

Dissolution can best be described as a tool that can provide valuable information about the availability of a drug product. In this study, nine different paracetamol tablet dosage forms available on the Turkish Drug Market have been investigated and physical controls were realized. Paddle and rotating basket apparatus methods were applied to all the formulations. In order to evaluate the dissolution rates, five different kinetics have been studied and the best fitting kinetics was found to be the Hixson-Crowell kinetics. It was found that all the preparations are in accordance with the Pharmacopeia standards.