Regenerative Treatment in Spinal Cord Injury

ÖZDEMİR M., ATTAR A., KUZU I.

CURRENT STEM CELL RESEARCH & THERAPY, cilt.7, sa.5, ss.364-369, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 7 Sayı: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.2174/157488812802481481
  • Dergi Adı: CURRENT STEM CELL RESEARCH & THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.364-369
  • Anahtar Kelimeler: Cell transplantation, marrow stromal cells, mesenchymal stem cells, regeneration, spinal cord, stem cells, tissue engineering., MARROW STROMAL CELLS, MESENCHYMAL STEM-CELLS, CENTRAL-NERVOUS-SYSTEM, MAGNETIC-RESONANCE TRACKING, COLONY-STIMULATING FACTOR, BONE-MARROW, FUNCTIONAL RECOVERY, CLINICAL-TRIAL, IN-VITRO, ADULT
  • Ankara Üniversitesi Adresli: Evet

Özet

Spinal cord injury is a devastating, traumatic event, and experienced mainly among young people. Until the modern era, spinal cord injury was so rapidly fatal that no seriously injured persons would survive long enough for regeneration to occur. Treatment of spinal cord injury can be summarized as follows: prevent further cord injury, maintain blood flow, relieve spinal cord compression, and provide secure vertebral stabilization so as to allow mobilization and rehabilitation, none of which achieves functional recovery. Previous studies have focused on analyzing the pathogenesis of secondary injury that extends from the injury epicenter to the periphery, as well as the tissue damage and neural cell death associated with secondary injury. Now, there are hundreds of current experimental and clinical regenerative treatment studies. One of the most popular treatment method is cell transplantation in injured spinal cord. For this purpose bone marrow stromal cells, mononuclear stem cells, mesenchymal stem cells, embryonic stem cells, neural stem cells, and olfactory ensheathing cells can be used. As a result, cell transplantation has become a promising therapeutic option for spinal cord injury patients. In this paper we discuss the effectiveness of stem cell therapy in spinal cord injury.