Recent Development of New Substituted Indole and Azaindole Derivatives as Anti-HIV Agents

Olgen S.

MINI-REVIEWS IN MEDICINAL CHEMISTRY, cilt.13, sa.12, ss.1700-1708, 2013 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 13 Sayı: 12
  • Basım Tarihi: 2013
  • Doi Numarası: 10.2174/13895575113139990075
  • Dergi Adı: MINI-REVIEWS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1700-1708
  • Anahtar Kelimeler: Antiviral, Indole and Azaindole Derivatives, Synthesis, HIV, Clinical Studies, REVERSE-TRANSCRIPTASE INHIBITORS, SOLID-PHASE SYNTHESIS, ATTACHMENT INHIBITOR, BIOLOGICAL EVALUATIONS, DRUG-RESISTANCE, PART 2, PHARMACOKINETICS, DISCOVERY, DESIGN, NNRTIS
  • Ankara Üniversitesi Adresli: Hayır

Özet

Human immunodeficiency virus-1 (HIV-1) infections cause global health problems. Indole derivatives have been considered as one of the promising HIV inhibitors. Recent inventions have focused on substituted indole and azaindole derivatives that possess unique antiviral activities against HIV-1. In this review, the evaluation of recent advances in substituted indole and azaindole derivatives for the treatment or prevention of HIV-1 and acquired immune deficiency syndrome (AIDS) has been focused. In this respect, compounds having drug and bio-active properties, including their synthesis and pharmacologic properties have been reported. In addition, anti-HIV properties of compounds, the structural features of inhibitors, the current progress in terms of therapeutic interventions and the leading groups in the field are discussed. Moreover, clinical and ADME (Absorption, Distribution, Metabolism, Elimination) properties of some clinically important compounds such as BMS-378806, L-737126 and IDX899 are reported.