Vancomycin elimination in human infants with intrauterine growth retardation

Frattarelli D., Ergun H., Lulic-Botica M., Lehr V., Aranda J.

PEDIATRIC INFECTIOUS DISEASE JOURNAL, cilt.24, sa.11, ss.979-983, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 11
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1097/01.inf.0000186283.95728.34
  • Dergi Adı: PEDIATRIC INFECTIOUS DISEASE JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.979-983
  • Anahtar Kelimeler: vancomycin, neonatology, therapeutic drug monitoring, intrauterine gowth retardation, drug elimination, RESTRICTED NEWBORN PIGLETS, LOW-BIRTH-WEIGHT, RENAL-FUNCTION, CLINICAL PHARMACOKINETICS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Intrauterine growth retardation (IUGR) results in substantial decrease in nephron number and renal and hepatic organ mass in experimental animals and newborn infants. Because the liver and the kidneys are the major organs for drug biotransformation and elimination, any decrease in their size and function may lead to impaired metabolism and elimination of drugs in newborns with IUGR. Our objective was to test the hypothesis that IUGR results in prolonged renal elimination of vancomycin in newborns.