Comparison of serum midkine levels between pregnant women with and without pre-eclampsia: A case-control study from a tertiary hospital

Sakcak B., Turgut E., Denizli R., Farisogullari N., Tanacan A., YAZIHAN N., ...Daha Fazla

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, cilt.162, sa.1, ss.287-291, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 162 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1002/ijgo.14677
  • Dergi Adı: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Gender Studies Database, MEDLINE, Public Affairs Index
  • Sayfa Sayıları: ss.287-291
  • Anahtar Kelimeler: biomarkers, inflammation, midkine, pre-eclampsia, risk prediction, UTERINE PERFUSION, PATHOPHYSIOLOGY, HYPERTENSION, REDUCTIONS, CELLS, RAT
  • Ankara Üniversitesi Adresli: Evet

Özet

ObjectiveTo evaluate changes in maternal serum midkine levels in pre-eclampsia. MethodsThis study included 40 pregnant women with pre-eclampsia and 66 healthy pregnant women in the control group. Demographic data, laboratory results, and midkine levels were compared between the groups. ResultsThe pre-eclampsia and control groups were similar in terms of demographics. The midkine level of pregnant women with pre-eclampsia was significantly higher than that of the controls (0.54 +/- 0.23 and 0.31 +/- 0.19 ng/mL, respectively, P < 0.001). According to the receiver operating characteristic analysis, the optimal cut-off value of midkine was determined as 0.37 ng/mL, at which it had 75% sensitivity and 74% specificity (area under the curve: 0.815, 95% confidence interval 0.73-0.89, P < 0.001). ConclusionThe serum midkine level was significantly higher in pregnant women with pre-eclampsia. Midkine seems to be associated with complicated inflammatory processes leading to pre-eclampsia. Further study protocols can be planned to investigate the role of midkine in the prediction of pre-eclampsia as a novel marker.