Effects of oral and intramuscular vitamin K prophylaxis on PIVKA-II assay parameters in breastfed infants in Turkey

Ulusahin N., Arsan S., Ertogan F.

TURKISH JOURNAL OF PEDIATRICS, cilt.38, sa.3, ss.295-300, 1996 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 3
  • Basım Tarihi: 1996
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.295-300
  • Anahtar Kelimeler: vitamin K1, neonate, PIVKA-II, hemorrhagic disease, LATE HEMORRHAGIC-DISEASE, DES-CARBOXY-PROTHROMBIN, NEWBORN, SUPPLEMENTATION, DEFICIENCY, BIRTH
  • Ankara Üniversitesi Adresli: Evet

Özet

Protein induced by vitamin K absence (PIVKA-II) has been used for the evaluation of vitamin K deficiency in the newborn. Differing PIVKA-II detection rates in various studies on hemorrhagic disease of the newborn have not been explained satisfactorily. In this study we investigated the PIVKA-II values of 44 healthy breastfed infants, of whom 29 recevied vitamin K1 either orally (N=13) or intramuscularly (n=16), and the remaining 15 constituted the control group. PIVKA-II was detected in 15.3 percent (2/13) of the oral and 25 percent of the (4/16) intramuscular group on the third day of life. The detection rate was 93.3 percent (14/15) in the control group. However, at the one-month follow-up, there were no PIVKA-II positive Infants. In conclusion, PIVKA-II positivity among breastfed Turkish infants on the third day of life was high compared to that in other studies, perhaps due to a delay in enzyme maturation related to racial, environmental and nutritional factors.