Purification of organic impurities from [O-18]H2O used for production of [F-18]fluoride as target material

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YILDIZ N., Ozkul D. K.

JOURNAL OF THE FACULTY OF ENGINEERING AND ARCHITECTURE OF GAZI UNIVERSITY, cilt.32, sa.2, ss.593-605, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.17341/gazimmfd.322186
  • Dergi Adı: JOURNAL OF THE FACULTY OF ENGINEERING AND ARCHITECTURE OF GAZI UNIVERSITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.593-605
  • Anahtar Kelimeler: [O-18]H2O, [(18) F] fluoride, cyclotron, ultrasonication, ozonolysis, ADVANCED OXIDATION PROCESSES, WATER, DEGRADATION, UV, PERFORMANCE
  • Ankara Üniversitesi Adresli: Evet

Özet

[F-18]fluoride, which is a positron emitting radioisotopes, is obtained by proton bombardment of [O-18] H2O as target material with accelarated protons in particle accelerators. Due to its high cost and very low natural abundance of [O-18] H2O, using of recyled [O-18] H2O after irradiation is more advantageous for many radiopharmaceutical production centers. However, irradiated [O-18] H2O contains impurities which result in low. [F-18] fluoride yields. So, purification of irradiated [O-18] H2O and using it for routin production of. [F-18] is important. In this study, to remove organic impurities from [O-18] H2O, which is used as target water to produce. [F-18] fluoride for F-18. FDG. (F-18 fluorodeoxyglucose) synthesis, ozonolysis, ultrasonication, distillation methods separately and their combined forms were applied to samples. The removing of acetone, acetonitrile and ethanol using a combination of ozonization+ ultrasonication method, the more suitable method for purification of [O-18] H2O, was found higher than that of ozonization and ultrasonication methods alone. While the yield of [F-18] FDG. from fresh [O-18] H2O was 72%, the yield of F-18. [FDG] from purified [O-18] H2O was 69%. The results showed that the decrease in [F-18] FDG. yield may be attributed to irradiation step only and obtained yield from purified irradiated [O-18] H2O using combined purification method was sufficient for clinical purpose.