Lycopene Protects Against Spontaneous Ovarian Cancer Formation in Laying Hens

Şahin K., Yenice E., Tuzcu M., Orhan C., Mızrak C., Şahin N., ...Daha Fazla

JOURNAL OF CANCER PREVENTION, cilt.23, sa.1, ss.25-36, 2018 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.15430/jcp.2018.23.1.25
  • Dergi Adı: JOURNAL OF CANCER PREVENTION
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.25-36
  • Anahtar Kelimeler: Lycopene, Ovarian cancer, Laying hen model, Chemoprevention, Transcription factors, TROUT ONCORHYNCHUS-MYKISS, CELL-CYCLE PROGRESSION, VITAMIN-A, ORAL-CONTRACEPTIVES, LIPID-PEROXIDATION, BREAST-CANCER, IN-VITRO, KAPPA-B, RISK, CAROTENOIDS
  • Ankara Üniversitesi Adresli: Hayır

Özet

Background: Dietary intake of lycopene has been associated with a reduced risk of ovarian cancer, suggesting its chemopreventive potential against ovarian carcinogenesis. Lycopene's molecular mechanisms of action in ovarian cancer have not been fully understood. Therefore, in the present study, we investigated the effects of lycopene on the ovarian cancer formation using the laying hen model, a biologically relevant animal model of spontaneous ovarian carcinogenesis due to high incidence rates similar to humans.