Akademik Veri Yönetim Sistemi
Bulgarian Journal of Veterinary Medicine, cilt.17, sa.2, ss.153-160, 2014 (Scopus)
Intestinal adenocarcinoma is a malignant tumour originating from the glandular intestinal epithelium. The tumour is relatively uncommon in cats. The most affected site in cats is the ileum when compared to other species. In the case, tubular type adenocarcinoma was diagnosed in the caudal part of duodenum of 1.5-year-old female Siamese cat. Two masses of different sizes were detected on the duodenum, protruding and obstructing the lumen. Histopathologically, anaplastic glandular epithelia tried to form tubules. The anaplastic cells invaded into tunica muscularis. Mononuclear cell infiltrations were present in all layers of the duodenum. The masses were evaluated immunohistochemically by the strept ABC method and different markers (Ki67, Her2neu, CEA and p63). The first three markers were positive in anaplastic glandular epithelial nuclei, cytoplasms and membrane in the propria of the mucosa and submucosa. Ki67 and Her2neu in particular, predicted the high malignancy of anaplastic cells and poor prognosis of tumour.