Determination of Fosfomycin Susceptibility in Escherichia coli Isolates by Various Methods

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ÖCAL D., TÜRK A. H., Lale E. S., Bayansar Z., Margun Z., Namli C., ...Daha Fazla

FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, cilt.27, sa.1, ss.94-102, 2022 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 1
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5578/flora.20229908
  • Dergi Adı: FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.94-102
  • Anahtar Kelimeler: Fosfomycin, Escherichia coli, Susceptibility testing, Agar dilution, KLEBSIELLA-PNEUMONIAE
  • Ankara Üniversitesi Adresli: Evet

Özet

Introduction: Because of its broad-spectrum activity and its safety profile, fosfomycin is often used as a first-line antibiotic for treating uncomplicated urinary tract infections. It is also one of the treatment options in various infections such as central nervous system, bone and joints, lung, soft tissue infections and sepsis. Escherichia coli is frequently encountered as a causative agent in such infections and is responsible for more than 80% of community-acquired urinary tract infections. There is a need to develop a fast and easily applicable test to evaluate the efficacy of fosfomycin. The aim of this study is to determine the susceptibility of fosfomycin in Escherichia coil isolates obtained from clinical isolates by various methods and to evaluate these methods in terms of ease of use, sensitivity, and specificity.