Fatal toxic effect of bleomycin on brain tissue after intracystic chemotherapy for a craniopharyngioma: Case report

Savas A., Erdem A., Tun K., Kanpolat Y.

NEUROSURGERY, cilt.46, sa.1, ss.213-216, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 1
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1093/neurosurgery/46.1.213
  • Dergi Adı: NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.213-216
  • Anahtar Kelimeler: bleomycin, chemotherapy, craniopharyngioma, cyst, stereotactic surgery, toxicity, CYSTIC CRANIOPHARYNGIOMA, MANAGEMENT, RADIATION, CHILDREN, THERAPY
  • Ankara Üniversitesi Adresli: Evet

Özet

OBJECTIVE AND IMPORTANCE: Craniopharyngiomas are benign neoplasms of epithelial origin that arise from the remnants of Rathke's pouch and are located in the sellar, parasellar, and third ventricular regions. Despite major advances in microsurgical techniques, total removal of these tumors is associated with a high risk of death, long-term endocrinological dependence, cognitive dysfunction, and behavioral disorders. For patients with monocystic craniopharyngiomas, encouraging postoperative survival rates and high rates of cyst regression after intracavitary administration of bleomycin have been reported. Moreover, only a few side effects have been reported for this treatment method, We report a patient with a cystic craniopharyngioma who was treated using intracavitary bleomycin administration and died as a result of the direct toxic effects of bleomycin on deep brain structures and the brainstem,