Geographic Atrophy Progression in Eyes with Age-Related Macular Degeneration: Role of Fundus Autofluorescence Patterns, Fellow Eye and Baseline Atrophy Area

ŞERMET F., Oguz Y. G., DEMİREL S., ÖZMERT E.

OPHTHALMIC RESEARCH, cilt.52, sa.2, ss.53-59, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1159/000361077
  • Dergi Adı: OPHTHALMIC RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.53-59
  • Anahtar Kelimeler: Age-related macular degeneration, Geographic atrophy, Fundus autofluorescence, Progression, RETINAL-PIGMENT EPITHELIUM, SCANNING LASER OPHTHALMOSCOPY, INDOCYANINE GREEN ANGIOGRAPHY, FACTOR-H POLYMORPHISM, JUNCTIONAL ZONE, LIPOFUSCIN, MACULOPATHY, PREVALENCE, ACCUMULATION, FLUORESCEIN
  • Ankara Üniversitesi Adresli: Evet

Özet

Background/Objective: To evaluate if fundus autofluorescence (FAF) patterns around geographic atrophy (GA) and the status of the fellow eye have an impact on GA progression. Methods: We included 54 eyes of 35 patients with GA. Areas of GA were quantified by RegionFinder software. Results: GA progression rates in eyes with a diffuse trickling pattern (median 1.42 mm(2)/year) were significantly higher than in normal eyes (median 0.22 mm(2)/year) and eyes with other diffuse FAF patterns (median 0.46 mm(2)/year). Eyes with a banded pattern had a significantly higher progression rate (median 0.81 mm(2)/year) than those without any FAF abnormalities (p = 0.038). The group with baseline total atrophy of the eyes <1 disk area (DA; median 0.42 mm(2)) had an inverse relation with GA progression compared to the groups with baseline atrophy >1 DA (p < 0.05). Conclusion: Diffuse trickling and banded patterns may have an impact on GA progression and may serve as prognostic factors. (C) 2014 S. Karger AG, Basel