Research Information System
Turkiye Klinikleri Jinekoloji Obstetrik, vol.22, no.1, pp.25-35, 2012 (Scopus)
Objective: To investigate whether maternal serum values of pregnancy associated plasma protein-A (PAPP-A), a component of first trimester screening test, are associated with pregnancy complications and to determine its value in predicting pregnancy complications. Material and Methods: In this study, the adverse pregnancy outcomes of the women who underwent first trimester screening test and had pregnancy follow-up in the antenatal clinic of our hospital, were evaluated according to PAPP-A values. Out of 15.886 pregnant women who had combinedscreening test, 2385 women with PAPP-A≤ 0.5 MoM were selected as the study group. 2210 women with PAPP-A MoM >0.5 were enrolled into the control group between the same dates. After exclusion of those patients with systemic diseases that affect pregnancy outcomes, cervical cerclage, and fetal anomalies, the remaining study group of 2170 women and the control group consisting of 2046 women were evaluated according to pregnancy complications such as abortion, preterm birth, preeclampsia and intrauterine growth retardation. Results: The correlations between low PAPP-A level (≤0.5 MoM) and preeclampsia (p<0.001), intrauterine growth failure (p< 0.001), preterm birth (p< 0.001), gestational diabetes mellitus (p= 0.040), oligohydramnios (p= 0.003), spontaneous abortus (p= 0.003), still birth (p< 0.001), were statistically significant. No statistically significant correlations were found between low PAPP-A level (≤0.5 MoM) and placenta previa (p= 0.496) and placental abruption (p= 0.110). Conclusion: Significant correlations were found between low PAPP-A level, and many pregnancy complications. But, PAPP-A alone remains insufficient in routine clinical evaluation of pregnancy complications because of its limited sensitivity. Copyright © 2012 by Türkiye Klinikleri.