Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure for cholangiocarcinoma

BALCI D., Sakamoto Y., Li J., Di Benedetto F., KIRIMKER E. O., Petrowsky H.

INTERNATIONAL JOURNAL OF SURGERY, cilt.82, ss.97-102, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 82
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.ijsu.2020.06.045
  • Dergi Adı: INTERNATIONAL JOURNAL OF SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.97-102
  • Anahtar Kelimeler: ALPPS, Perihilar cholangiocarcinoma, Intrahepatic cholangiocarcinoma, Portal vein embolization, BILE-DUCT CANCER, PERIHILAR CHOLANGIOCARCINOMA, EXTENDED HEPATECTOMY, BILIARY CANCER, 1ST SERIES, EMBOLIZATION, CARCINOMA, RESECTION, MORTALITY, SURGERY
  • Ankara Üniversitesi Adresli: Evet

Özet

Perihilar cholangiocarcinoma (PHCC) has been a great challenge for surgeons, requiring advanced skills and expertise and was often associated with high morbidity and mortality. Resectability rates are up to 75% even in experienced centers. In patients with PHCC, radical liver and bile duct resection aiming R0 surgical margins offers the best long-term survival. Therefore, extensive resections with low FLR are commonly needed and PVE is offered to induce remnant liver hypertrophy for a long period. Associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) is considered a promising approach inducing rapid remnant hypertrophy to prevent dropouts due to complications or tumor progression and increase resectability. Although poor results were reported initially, refinements in technique and risk adjustment of patient selection improved outcomes. The procedure is still under debate for the indication of PHCC. This article reviews the current literature on ALPPS in treatment of perihilar and intrahepatic cholangiocarcinoma.