A zinc oxide nanorods/molybdenum disulfide nanosheets hybrid as a sensitive and reusable electrochemical sensor for determination of anti-retroviral agent indinavir

Mehmandoust M., Karimi F., ERK N.

CHEMOSPHERE, cilt.300, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 300
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.chemosphere.2022.134430
  • Dergi Adı: CHEMOSPHERE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Artic & Antarctic Regions, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Environment Index, Food Science & Technology Abstracts, Geobase, Greenfile, MEDLINE, Metadex, Pollution Abstracts, Public Affairs Index, Veterinary Science Database, Civil Engineering Abstracts
  • Anahtar Kelimeler: Sensing application, Voltammetry, Indinavir, Real samples, GLASSY-CARBON ELECTRODE, HUMAN PLASMA, LAYER MOS2, PROTEASE INHIBITOR, PASTE ELECTRODE, ASCORBIC-ACID, FABRICATION, TRYPTOPHAN, NANOTUBES, BIOSENSOR
  • Ankara Üniversitesi Adresli: Evet

Özet

This work aims to develop an electrochemical sensor for the reusable and selective detection of trace levels of indinavir (IDV) as an anti-retroviral drug by using zinc oxide nano-rods/molybdenum disulfide nanosheets on a screen-printed electrode (ZnO NRs/MoS2 NSs/SPE). Quantitative IDV detection was achieved using differential pulse voltammetry (DPV). The assay specificity was illustrated using interfering species and exhibited high specificity toward the IDV. The developed displayed a wide dynamic range, from 0.01 to 0.66 and 0.66-7.88 mu M in Britton-Robinson (B-R) buffer, with a 0.007 mu M limit of detection. The fabricated ZnO NRs/MoS2 NSs/SPE electrode exhibited high sensitivity, stability, good reproducibility, and repeatability towards the sensing of IDV. It turned out that the hybrid electrochemical sensor's sensing performance was remarkably improved due to the synergistic effect between MoS2 NSs and ZnO NRs, where the former affords a large active surface area and quick electron transfer. The reported sensor provides a new alternative for electrochemical detection of IDV and could expand the applications of metal nanoparticles in emerging technologies for monitoring drugs in real samples.