Molecularly imprinted polymers: preparation, characterisation, and application in drug delivery systems

Yüksel N., Tektaş S.

JOURNAL OF MICROENCAPSULATION, cilt.39, sa.2, ss.176-196, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/02652048.2022.2055185
  • Dergi Adı: JOURNAL OF MICROENCAPSULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.176-196
  • Anahtar Kelimeler: Molecular imprinting, polymerisation, template, drug delivery, controlled, sustained release, ophthalmic, oral, parenteral, transdermal, ENANTIOSELECTIVE-CONTROLLED DELIVERY, ANALOG BUILT POLYMERS, CONTROLLED-RELEASE, SUSTAINED-RELEASE, GRAPHENE OXIDE, RECOGNITION, NANOPARTICLES, MIP, 5-FLUOROURACIL, MICROSPHERES
  • Ankara Üniversitesi Adresli: Evet

Özet

Molecular imprinting technology defines the creation of molecularly imprinted polymer (MIP) molecules in which template molecules can place in a key-lock relationship through shape, diameter, and functional groups. Although molecular imprinting technology has been employed in different fields, its applications in drug delivery systems (DDSs) have gained momentum recently. The high loading efficiency, high stability, and controlled drug release are the primary advantages of MIPs. Here, the main components, preparation methods, and characterisation tests of MIPs are summarised, and their applications in DDSs administered by different routes are evaluated in detail. The review offers a perspective on molecular imprinting technology and applications of MIPs in drug delivery by surveying the literature approximately 1998-2021 together with the outlined prospects.