Akademik Veri Yönetim Sistemi
Journal of Clinical and Analytical Medicine, cilt.3, sa.4, ss.442-447, 2012 (SCI-Expanded)
© 2017, Derman Medical Publishing. All rights reserved.Aim: The aim of this study is to compare the preventive effects of methyl prednisolone sodium succinate (MPSS) and ATP-MgCl2 on secondary injury after spinal cord trauma by clinical, electrophysiological and histopathological examination. Material and Method: Thirty healthy male Wistar-Albino rats were used in the study. All rats were evaluated by inclined plane, toe-spread and tarlov tests. Before the operation, somatosensoric evoked potentials (SEP) and motor evoked potentials (MEP) were recorded from anesthetized rats. The spinal cord was traumatised by Allen’s weight drop method applying 50gr/cm force. The rats were divided into 3 groups of 10 members per group (1st group FTS, 2nd group-MP, 3rd group ATP). The first group received saline, the second group received MPSS, and the third group received ATPMgCl2. At regular intervals after the operation, these tests were repeated on the rats. At the 72nd hour after operation, their SEP and MEP values were recorded again. The damaged spinal cord segment stained with hematoxylin - eosin was evaluated histopathologically. Results: Qualitative SEP scales and Tarlov scales were found compatible. MP and ATP groups were found significantly better than control group (FTS) according to some electrophysiological results. However, a significant difference could not be determined between MPSS and ATP-MgCl2 applied groups. Histopathological examinations showed the presence of MPSS caused polymorphonuclear cell reaction. Discussion: As a result, more experimental studies are needed to say that ATP-MgCl2 is more effective than MPSS in spinal cord injury (SCI).