Decreased therapeutic effects of noscapine combined with imatinib mesylate on human glioblastoma in vitro and the effect of midkine

Erguven, Mine; Bilir, Ayhan; YAZIHAN, NURAY; Ermis, Ezgi; Sabanci, Akin; Aktas, Esin; Aras, Yavuz; Alpman, Vehbi

doi:10.1186/1475-2867-11-18

Decreased therapeutic effects of noscapine combined with imatinib mesylate on human glioblastoma in vitro and the effect of midkine

Erguven M., Bilir A., YAZIHAN N., Ermis E., Sabanci A., Aktas E., ...Daha Fazla

CANCER CELL INTERNATIONAL, cilt.11, 2011 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 11
Basım Tarihi: 2011
Doi Numarası: 10.1186/1475-2867-11-18
Dergi Adı: CANCER CELL INTERNATIONAL
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Ankara Üniversitesi Adresli: Evet

Özet

Background: Glioblastoma (GBM) develops resistance to the advances in chemotherapy leading to poor prognosis and life quality. Consequently, new treatment modalities are needed. Our aims were to investigate the effects of combined noscapine (NOS) and imatinib mesylate (IM) on human GBM in vitro and the role of midkine (MK) in this new combination treatment.