Interferon-gamma assays for the diagnosis of tuberculosis infection before using tumour necrosis factor-alpha blockers

Cobanoglu N., Ozcelik U., Kalyoncu U., Ozen S., Kiraz S., Gurcan N., ...Daha Fazla

International Journal of Tuberculosis and Lung Disease, cilt.11, sa.11, ss.1177-1182, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 11
  • Basım Tarihi: 2007
  • Dergi Adı: International Journal of Tuberculosis and Lung Disease
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1177-1182
  • Anahtar Kelimeler: interferon-gamma, tuberculosis infection, turnout necrosis factor-alpha blockers, immunosuppression, CALMETTE-GUERIN VACCINATION, MYCOBACTERIUM-TUBERCULOSIS, LATENT TUBERCULOSIS, SKIN-TEST, BLOOD-TEST, BCG, REACTIVATION, ENUMERATION
  • Ankara Üniversitesi Adresli: Hayır

Özet

OBJECTIVES: Patients who receive tumour necrosis factor-alpha (TNF-α) blockers are mostly immunosuppressed. A study was performed to investigate whether an interferon-gamma (IFN-γ) assay could represent an alternative approach to the tuberculin skin test (TST) for the diagnosis of latent tuberculosis infection (LTBI) in these patients. DESIGN: We prospectively enrolled 106 individuals into the study in two groups. Group 1 consisted of 38 healthy individuals and Group 2 included 68 patients with chronic inflammatory diseases evaluated for LTBI before the use of TNF-α blockers. RESULTS: Of all participants, nine had indeterminate IFN-γ test results. Agreement between the two tests was poor in both groups (κ values respectively -0.54 and 0.18). In a total of 97 subjects, 10 (10.3%) were positive by the IFN-γ test and 49 (50.5%) by TST. CONCLUSION: We found poor agreement between TST and the IFN-γ test in our study. Our limited preliminary data should be accepted as a basis for designing future studies that will be helpful for physicians to decide whether the IFN-γ test is more sensitive than the TST test in detecting LTBI before the use of TNF-α blockers. © 2007 The Union.