Association of monocyte-to-high density lipoprotein-cholesterol ratio with peripheral neuropathy in patients with Type II diabetes mellitus

Gökçay Canpolat A., Emral R., Keskin C., Canlar S., Şahin M., Çorapçıoğlu D.

BIOMARKERS IN MEDICINE, cilt.13, sa.11, ss.907-915, 2019 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 11
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2217/bmm-2018-0451
  • Dergi Adı: BIOMARKERS IN MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.907-915
  • Anahtar Kelimeler: diabetic neuropathy, inflammation, monocyte count to high-density lipoprotein cholesterol ratio, oxidative stress, CARDIOVASCULAR EVENTS, MACROPHAGES, MARKERS, FEATURES, DISEASE, LIPIDS
  • Ankara Üniversitesi Adresli: Evet

Özet

We assessed the association of monocyte count to high-density lipoprotein cholesterol ratio (MHR) with diabetic peripheral neuropathy (DPN) and its role as a marker for identification of high-risk patients for DPN. Methods: A total of 180 patients with Type II diabetes mellitus (T2DM) were enrolled in the study. MHR, erythrocyte sedimentation rate and serum CRP along with other tests for T2DM and DPN were measured. Results: Duration of T2DM (p = 0.013), insulin use (p = 0.006) and serum CRP levels (p = 0.008) were significantly higher in patients with DPN. MHR was similar between groups (p = 0.447). Duration of diabetes (OR: 1.048; p = 0.038) and the serum CRP levels (OR: 1.073; p = 0.026) were found as independent predictors for the presence of DPN, however, MHR was not. Conclusion: Higher MHR indicates an enhanced inflammation and oxidative stress which was not found to be associated with the presence of DPN.