Research Information System
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI, vol.54, no.3, pp.171-176, 2007 (SCI-Expanded)
The purpose of this study is to investigate amoxicillin sodium and trihydrate which is one of the drugs widely used on goats and not having enough information about pharmacokinetics in Kilis goats. In this study, a total of 31 Kilis goats were used in this study. The goats were divided into 5 groups with 7 animals in each group (Group 1, Group 2, Group 3, Group 4) and a 5th group with 3 goats. Amoxicillin trihydrate was given to the Group 1 animals (as control group) by i.v. (vena jugularis) at the dose level of 10 mg/kg, 10 mg/kg amoxicillin i.m. (musculus semitendinosus) was given to Group 2, 10 mg/kg long action amoxicillin i.m. was given to Group 3, 10 mg/kg amoxicillin was given by orally to Group 4 and 15 mg/kg long action amoxicillin i.m. was given to Group 5. Following i.v., i.m. and oral administration, blood samples were taken from left vena jugularis of each goat in groups and collected CaEDTA through a cannulla. Plasma was seperated by centrifugation and analysed by microbiological agar gel diffusion method and amoxicillin amounts in plasma were determined. The area under the curve (EAA) was calculated as 36.20 +/- 1.75 mu g.hour/ml after amoxicillin was administered i.v., 33.03 +/- 1.66 mu g.hour/ml after amoxicillin was administered i.m., 31.37 +/- 2.21 mu g.hour/ml and 44.54 +/- 1.22 mu g.hour/ml after long action amoxicillin after 10 mg/kg and 15 mg/kg doses were administered i.m., 12.46 +/- 1.54 mu g.hour/ml after amoxicillin oral administration. The maximum plasma drug concentration (C-max), was found as follows: amoxicillin i.v. 7.76 mu g/ml, amoxicillin i.m. 5.09 mu g/ml, long action amoxicillin, 10 mg/kg and 15 mg/kg doses i.m., respectively, 3.68 mu g/ml and 5.57 mu g/ml, oral administration of amoxicillin 1.48 mu g/ml. Time to reach maximum plasma drug concentration (T-max) was found at 45 minutes after amoxicillin was administered via i.m., at 90 minutes and 8 hours after long action amoxicillin 10 mg/kg and 15 mg/kg doses i.m. administration and at 2 hours after oral administration. In conclusion, this study proved that amoxicillin after 10 mg/kg dose i.m. administration is more effective than the others in terms of pharmacokinetics parameters. However long action amoxicillin i.m. administration of 10 mg/kg and 15 mg/kg doses were found to be effective in maintaining continuous antibacterial activity and drug concentration in plasma and tissues after administration from 24 to 36 hours of i.m. as a result it is stated that both of the drug formulations can be used effectively in clinical treatment.