Current Review of Iron Overload and Related Complications in Hematopoietic Stem Cell Transplantation

Creative Commons License

Atilla E., TOPRAK S. K., DEMİRER T.

TURKISH JOURNAL OF HEMATOLOGY, cilt.34, sa.1, ss.1-9, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 34 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tjh.2016.0450
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1-9
  • Anahtar Kelimeler: Iron overload, Hematopoietic stem cell transplantation, Ferritin, Iron chelation, HIGH-DOSE CHEMOTHERAPY, VERSUS-HOST-DISEASE, AUTOLOGOUS BONE-MARROW, SINUSOIDAL OBSTRUCTION SYNDROME, NONTRANSFERRIN-BOUND IRON, LONG-TERM SURVIVORS, BREAST-CANCER, LIVER DYSFUNCTION, PROGNOSTIC IMPACT, SERUM FERRITIN
  • Ankara Üniversitesi Adresli: Evet

Özet

Iron overload is an adverse prognostic factor for patients undergoing hematopoietic stem cell transplantation (HSCT). In the HSCT setting, pretransplant and early posttransplant ferritin and transferrin saturation were found to be highly elevated due to high transfusion requirements. In addition to that, post-HSCT iron overload was shown to be related to infections, hepatic sinusoidal obstruction syndrome, mucositis, liver dysfunction, and acute graft-versus-host disease. Hyperferritinemia causes decreased survival rates in both pre-and posttransplant settings. Serum ferritin levels, magnetic resonance imaging, and liver biopsy are diagnostic tools for iron overload. Organ dysfunction due to iron overload may cause high mortality rates and therefore sufficient iron chelation therapy is recommended in this setting. In this review the management of iron overload in adult HSCT is discussed.