Comparative Study for the Determination of Gemifloxacin by HPLC and Microbiological Methods from Pharmaceutical Preparations and Biological Samples

Kiymaci M. E., Gumustas A., Gümüştaş M., Akin A., Özkan S. A.

CURRENT PHARMACEUTICAL ANALYSIS, cilt.11, sa.3, ss.193-200, 2015 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2174/1573412911666150305001657
  • Dergi Adı: CURRENT PHARMACEUTICAL ANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.193-200
  • Anahtar Kelimeler: Gemifloxacin, HPLC, microbiology, validation, biological samples, pharmaceuticals, LIQUID-CHROMATOGRAPHY, DOSAGE FORMS, HUMAN SERUM, MESYLATE, FORMULATIONS, ASSAY, BULK, PHARMACOKINETICS, SUSCEPTIBILITY, VALIDATION
  • Ankara Üniversitesi Adresli: Evet

Özet

The fluoroquinolones have broad-spectrum activity, good absorption in gastrointestinal canals and superior tissue penetration. Because of these properties, they have been used to treat a wide range of infections. In this study high performance, liquid chromatography and microbiological methods have been developed for the determination of Gemifloxacin (GEM) in pharmaceutical preparations and human plasma.