Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Dermatoloji, cilt.33, sa.2, ss.73-82, 2023 (Scopus)
Isotretinoin is a synthetic retinoid derived from retinol. Systemic isotretinoin has been used for years in the treatment of severe acne vulgaris. Isotretinoin is the only drug that acts alone on the 4 etiopathogenic factors of acne vulgaris. In addition, systemic isotretinoin can be used in many dermatological diseases other than acne vulgaris with its immunomodulatory, anti-inflammatory, anti-tumor, anti-angiogenic effects. It acts on T and B lymphocytes with its immunomodulatory effect, on polymorphonuclear leukocytes with its anti-inflammatory effect, on gene expression with its anti-tumor effect and on endothelial cells and keratinocytes with its anti-angiogenic effect. The use of systemic isotretinoin in dermatological diseases other than acne has been increasing in recent years. The main uses of isotretinoin other than acne; inflammatory dermatoses (rosacea, psoriasis, hidradenitis suppurativa, pityriasis rubra pilaris), infectious diseases (flat warts, condyloma acuminata), sebaceous gland pathologies (seborrhea, seborrheic dermatitis, sebaceous hyperplasia, sebaceous adenoma), cicatricial alopecias (dissecting cellulitis, folliculitis decal-vans, frontal fibrosing alopecia), non-melanoma skin cancers (actinic keratosis, squamous cell carcinoma, basal cell carcinoma, cutaneous T-cell lymphoma, xeroderma pigmentosum, Gorlin Goltz syndrome, epidermodysplasia verrusiformis), cosmetic dermatology (photoaging, after rhinoplasty operation) and keratinization disorders (ichthyoses, erythrokeratodermas, palmoplantar keratodermas, Darier's disease, Hailey-Hailey disease). Apart from these, there are case reports and series indicating that isotretinoin is beneficial in many dermatological diseases. However, more studies are needed to clarify exactly how and when isotretinoin can be used in most of these dermatological conditions.