Using dimensional models of externalizing psychopathology to aid in gene identification

Dick D. M., Aliev F., Wang J. C., Grucza R. A., Schuckit M., Kuperman S., ...More

ARCHIVES OF GENERAL PSYCHIATRY, vol.65, no.3, pp.310-318, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1001/archpsyc.65.3.310
  • Journal Name: ARCHIVES OF GENERAL PSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Page Numbers: pp.310-318
  • Ankara University Affiliated: Yes

Abstract

Context: Twin studies provide compelling evidence that alcohol and drug dependence, childhood conduct disorder, adult antisocial behavior, and disinhibitory personality traits share an underlying genetic liability that contributes to a spectrum of externalizing behaviors. However, this information has not been widely used in gene identification efforts, which have focused on specific disorders diagnosed using traditional psychiatric classification systems.