EFFECTS OF FLUMAZENIL ON ETHANOL WITHDRAWAL SYNDROME IN RATS

UZBAY I., AKARSU E. S., KAYAALP S.

ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, cilt.45-1, sa.2, ss.120-124, 1995 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45-1 Sayı: 2
  • Basım Tarihi: 1995
  • Dergi Adı: ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.120-124
  • Anahtar Kelimeler: BENZODIAZEPINE ANTAGONIST, CAS 78755-81-4, ETHANOL WITHDRAWAL SYNDROME EXPERIMENTAL, FLUMAZENIL, RO 15-1788, PHARMACOLOGY, BENZODIAZEPINE RECEPTOR ANTAGONISTS, PHYSICAL-DEPENDENCE, ALCOHOL-WITHDRAWAL, AUDIOGENIC-SEIZURES, RO 15-1788, RO-15-1788, DIAZEPAM, PRECIPITATION, ANXIETY, LIGAND
  • Ankara Üniversitesi Adresli: Evet

Özet

Effects of flumazenil (Ro 15-1788, CAS 78755-81-4) on ethanol withdrawal syndrome (EWS) has been investigated in rats. Behavioral EWS symptoms appeared during the first 6 h of ethanol withdrawal. Flumazenil (2.5 and 10 mg/kg i.p.) ina eased horizontal and vertical locomotor activity significantly and also precipitated abnormal gait and agitation at the beginning of EWS in a dose dependent manner. However, thereafter it reduced the severity of abnormal posture and gait, tail stiffness, agitation and stereotyped behavior in a dose dependent manner. At the 6th hour of EWS, flumazenil (10 mg/kg) reduced total EWS score significantly, but shortened the latency of audiogenic seizures and increased the severity of wet dog shakes.