CYP1A1, GST gene polymorphisms and risk of chronic myeloid leukemia.

Taspinar M., Aydos S. E., Comez O., ELHAN A. H., KARABULUT H. G., SUNGUROĞLU A.

Swiss medical weekly, cilt.138, sa.1-2, ss.12-7, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 138 Sayı: 1-2
  • Basım Tarihi: 2008
  • Dergi Adı: Swiss medical weekly
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.12-7
  • Anahtar Kelimeler: CYP1A1, GSTT1, GSTM1, polymorphisms, CML, GLUTATHIONE-S-TRANSFERASE, CYTOCHROME P4501A1 POLYMORPHISMS, ACUTE LYMPHOBLASTIC-LEUKEMIA, PROSTATE-CANCER, COMBINED GENOTYPES, SUSCEPTIBILITY, M1, T1, TOBACCO, CYP2D6
  • Ankara Üniversitesi Adresli: Evet

Özet

Principles: Associations between polymorphisms for genes encoding enzymes involved in biotransformation of xenobiotics and susceptibility to several cancers have been shown in several studies. The aim of the present study is to investigate the influence of cytochromes P450 (CYP450) 1A1*2C and Glutathione S-transferases (GSTs) (T1 and M1) gene polymorphisms in susceptibility to chronic myeloid leukaemia (CML).