Synthesis, antifungal and antioxidant screening of some novel benzimidazole derivatives

Kerimov I., KILCIGİL G., EKE B., Altanlar N., Iscan M.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.22, sa.6, ss.696-701, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/14756360701228558
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.696-701
  • Anahtar Kelimeler: thiosemicarbazides, thiadiazolylmethylbenzimidazoles, triazolylmethylbenzimidazoles, antimicrobial activity, antioxidant activity, lipid peroxidation, LIPID PEROXIDE FORMATION, LIVER
  • Ankara Üniversitesi Adresli: Evet

Özet

Some novel benzimidazole derivatives were synthesized and their in vitro effects on rat liver microsomal NADPHdependent lipid peroxidation ( LP) level, ethoxyresorufin O-deethylase ( EROD) and antifungal activities were determined. A significant decrease in male rat liver microsomal LP level was noted by compounds 4c (52%), 4e (58%) and 4h (43%) at 10 23 M concentration. Compounds 4c (100.0%), 4h ( 100.0%), 5c (98.0%) and 5h (100.0%) inhibited the microsomal ethoxyresorufin O-deethylase ( EROD) enzyme activity better than that of the specific inhibitor caffeine (85%). Among these compounds, only compounds 4b and 4h exhibited moderate activity against C. albicans whereas the others had weak effects.