HELICOBACTER, cilt.25, sa.5, 2020 (SCI-Expanded)
Background Autoimmune atrophic gastritis (AIG) is very rare in children. Despite a better understanding of histopathologic changes and serological markers in this disease, underlying etiopathogenic mechanisms and the effect ofHelicobacter pylori(H pylori) infection are not well known. We aimed to investigate the relation between AIG andH pyloriinfection in children. Materials and Methods We evaluated the presence of AIG andH pyloriinfection in fifty-three patients with positive antiparietal cell antibody (APCA). Demographic data, clinical symptoms, laboratory and endoscopic findings, histopathology, and presence ofH pyloriwere recorded. Results The children were aged between 5 and 18 years, and 28 (52.8%) of them were male. Mean age was 14.7 +/- 2.6 years (median: 15.3; min-max: 5.2-18), and 10 (18.8%) of them had AIG confirmed by histopathology. In the AIG group, the duration of vitamin B12 deficiency was longer (P = .022), hemoglobin levels were lower (P = .018), and APCA (P = .039) and gastrin (P = .002) levels were higher than those in the non-AIG group. Endoscopic findings were similar between the two groups. Intestinal metaplasia was higher (P = .018) in the AIG group. None of the patients in the AIG group hadH pyloriinfection (P = .004). One patient in the AIG group had enterochromaffin-like cell hyperplasia. Conclusions Our results show that, in children,H pyloriinfection may not play a role in AIG. AIG could be associated with vitamin B12 deficiency, iron deficiency, and APCA positivity in children. APCA and gastrin levels should be investigated for the early diagnosis of AIG and intestinal metaplasia.