Simultaneous quantitative resolution of irbesartan and hydrochlorothiazide in a pharmaceutical dosage form by signal processing techniques

ÜSTÜNDAĞ Ö., DİNÇ E.

Fabad Journal of Pharmaceutical Sciences, cilt.38, sa.1, ss.25-32, 2013 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 1
  • Basım Tarihi: 2013
  • Dergi Adı: Fabad Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.25-32
  • Anahtar Kelimeler: Continuous wavelet transform, Hydrochlorothiazide, Irbesartan, Quantitative analysis, Signal processing techniques
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, the continuous wavelet transform (CWT) was applied to the original absorption spectra and their ratio spectra for the determination of irbesartan (IRB) and hydrochlorothiazide (HCT) in a tablet dosage form. The proposed signal processing methods do not require a preliminary separation procedure. Calibration graphs were obtained by measuring CWT signals of the original spectra and ratio spectra at 243.0 nm and 235.9 nm for IRB and 273.8 nm and 262.8 nm for HCT, respectively. The validation of the proposed CWT methods was performed by using recovery studies, standard addition experiments and inter-day and intra-day analyses. The proposed CWT signal processing methods were successfully applied to the simultaneous quantitative estimation of IRB and HCT in tablets.