Oogonial Precursor Cell-Derived Autologous Mitochondria Injection to Improve Outcomes in Women With Multiple IVF Failures Due to Low Oocyte Quality: A Clinical Translation

Oktay K., Baltaci V., SÖNMEZER M., Turan V., Unsal E., Baltaci A., ...Daha Fazla

REPRODUCTIVE SCIENCES, cilt.22, sa.12, ss.1612-1617, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 12
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1177/1933719115612137
  • Dergi Adı: REPRODUCTIVE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1612-1617
  • Anahtar Kelimeler: oogonial precursor cells, mitochondria, embryo transfer, pregnancy, oocyte quality, IVF, STEM-CELLS, CRYOPRESERVATION, OVARY
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Mitochondrial dysfunction has been suggested as a major cause of age-induced decline in oocyte quality. In the past, donor oocyte cytoplasmic transfer showed some success but was abandoned due to the concerns with heteroplasmy. Recent studies indicated presence of oogonial precursor cells (OPCs) in the human ovary, which could be an autologous source of healthy mitochondria. We sought to investigate the clinical efficacy of OPC-derived autologous mitochondrial injection (AMI) to improve oocyte quality in women with multiple in vitro fertilization (IVF) failures.