Oogonial Precursor Cell-Derived Autologous Mitochondria Injection to Improve Outcomes in Women With Multiple IVF Failures Due to Low Oocyte Quality: A Clinical Translation

Oktay K., Baltaci V., SÖNMEZER M., Turan V., Unsal E., Baltaci A., ...More

REPRODUCTIVE SCIENCES, vol.22, no.12, pp.1612-1617, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 12
  • Publication Date: 2015
  • Doi Number: 10.1177/1933719115612137
  • Journal Name: REPRODUCTIVE SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1612-1617
  • Keywords: oogonial precursor cells, mitochondria, embryo transfer, pregnancy, oocyte quality, IVF, STEM-CELLS, CRYOPRESERVATION, OVARY
  • Ankara University Affiliated: Yes

Abstract

Background: Mitochondrial dysfunction has been suggested as a major cause of age-induced decline in oocyte quality. In the past, donor oocyte cytoplasmic transfer showed some success but was abandoned due to the concerns with heteroplasmy. Recent studies indicated presence of oogonial precursor cells (OPCs) in the human ovary, which could be an autologous source of healthy mitochondria. We sought to investigate the clinical efficacy of OPC-derived autologous mitochondrial injection (AMI) to improve oocyte quality in women with multiple in vitro fertilization (IVF) failures.