The fate of recipient-derived hepatocytes in sex-mismatched liver allograft following liver transplantation

Idilman R., Erden E., KUZU I., Ersoz S., Karayalcin S.

CLINICAL TRANSPLANTATION, cilt.21, sa.2, ss.202-206, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1111/j.1399-0012.2006.00623.x
  • Dergi Adı: CLINICAL TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.202-206
  • Anahtar Kelimeler: hepatocyte, liver transplantation, regenerative medicine, repopulation, stem cells, BONE-MARROW-CELLS, STEM-CELLS, FUSION, MICROCHIMERISM, MICE, REGENERATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: ''Bone marrow-derived stem cells'' have attracted great attention as potential candidates for liver-directed gene therapy and as a tool for regenerative medicine. However, the fate of these cells is not well-known. The aim of this present study was to investigate the fate of ''recipient-derived repopulated hepatocytes'' in sex-mismatched liver allografts in individuals following liver transplantation during systematic longitudinally performed liver biopsies.