A review of current progress in gene and stem cell therapy for erectile dysfunction

GÜR S., Kadowitz P. J., Hellstrom W. J. G.

EXPERT OPINION ON BIOLOGICAL THERAPY, cilt.8, sa.10, ss.1521-1538, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 8 Sayı: 10
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1517/14712598.8.10.1521
  • Dergi Adı: EXPERT OPINION ON BIOLOGICAL THERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1521-1538
  • Anahtar Kelimeler: cell based therapy, cGMP, endothelial progenitor cells, nitric oxide, ENDOTHELIAL PROGENITOR CELLS, NITRIC-OXIDE SYNTHASE, HEPATOCYTE GROWTH-FACTOR, RAT CORPUS CAVERNOSUM, HIGH BLOOD-PRESSURE, RISK-FACTORS, OXIDATIVE STRESS, SMOOTH-MUSCLE, BONE-MARROW, MYOCARDIAL-INFARCTION
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Current gene-based strategies for treatment of erectile dysfunction (ED) are based on the nitric oxide (NO)/cGMP system; although growth factors, calcium sensitization, and potassium channel expression have been studied. Initial investigations of stem-cell-based therapy have attracted attention. Results of the first gene transfer clinical trial for treatment of ED with maxi-K channels are positive. Moreover, there is progress in gene and stem-cell therapy for the treatment of cardiovascular (CV) diseases. Objective: To improve understanding of gene and stem-cell therapy for CV disease, with emphasis on ED. Methods: Review of current literature. Results/conclusion: Treatment and prevention of ED can be improved by the application of CVD gene/cell-based therapy. New discoveries based on gene- and cell-based therapy will lead to new advances in the treatment of ED.