Ga-68-PSMA PET/CT for Patients with PSA Relapse after Radical Prostatectomy or External Beam Radiotherapy

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von Eyben F. E., SOYDAL Ç., von Eyben R.

DIAGNOSTICS, cilt.11, sa.4, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3390/diagnostics11040622
  • Dergi Adı: DIAGNOSTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, INSPEC, Directory of Open Access Journals
  • Anahtar Kelimeler: Ga-68-PSMA positron emission tomography, computed tomography (PET/CT), non-metastatic prostate cancer, oligometastatic prostate cancer, overall survival (OS), prostate-specific membrane antigen (PSMA), prostate-specific antigen (PSA) relapse, salvage treatment, CANCER-SPECIFIC MORTALITY, BIOCHEMICAL RECURRENCE, SALVAGE RADIOTHERAPY, CURATIVE TREATMENT, RADIATION-THERAPY, NATURAL-HISTORY, METASTASIS-FREE, DOUBLING TIME, RISING PSA, MEN
  • Ankara Üniversitesi Adresli: Evet

Özet

The study aimed to summarize clinical characteristics associated with Gallium-68-prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (Ga-68-PSMA PET/CT) scans as patients were restaged for prostate-specific antigen (PSA) relapse after radical prostatectomy (RP) or external beam radiotherapy (EBRT). Our analyses included multiple cox regression analyses. The study evaluated 95 patients with rising values of PSAs after RP and after EBRT. Sixty 63% of patients had a positive Ga-68-PSMA PET/CT scan. Twelve patients (13%) had a positive site in the prostate bed, 29 patients (30%) had a positive site in the regional lymph nodes, and 19 (20%) had positive sites in distant organs. After four years follow-up, 21 patients (22%) died. Using multiple Cox regression analyses, the number of positive sites on the Ga-68-PSMA PET/CT scan significantly predicted overall survival (OS) (p = 0.0001), whereas risk score and regional locations of the positive sites were not significant in the multiple Cox regression analyses. Our study indicates that the specific findings of Ga-68-PSMA PET/CT scans are important because detailed findings of the scans predict the outcome after salvage treatment of patients with PSA relapse examined with Ga-68-PSMA PET/CT scans.