Akademik Veri Yönetim Sistemi
Ankara Üniversitesi Eczacılık Fakültesi Dergisi, cilt.47, sa.2, ss.508-519, 2023 (Scopus)
Objective: This study aims to prepare and evaluate time-controlled drug delivery system of telmisartan. Telmisartan has low aqueous solubility, which is its major drawback. The solubility of the drug enhanced by using solid dispersion method and compression coated chronotherapeutic tablets were formulated. Material and Method: Solid dispersion of telmisartan was prepared by melting method. Direct compression method was used to prepare telmisartan containing core tablets and tablets were coated by compression-coating method. Prepared tablets were characterized in terms of hardness, diameter, and thickness. In order to demonstrate the pulsatile release, the tablets were subjected to USP Apparatus II dissolution test. Result and Discussion: Solid dispersion of telmisartan increased the solubility of telmisartan significantly (p<0.05). Compression-coated tablets were obtained with suitable hardness values (149.833±5.862-205.367±3.955 N) and telmisartan was released with lag times of 120-540 min which are suitable for chronopharmaceutic application.