Pyrazoline and Hydrazone Derivatives as Potent Membrane Stabilizer and Antioxidant Compounds

Aksoz B. E., Sarialtın S., ÇOBAN T.

Pharmaceutical Chemistry Journal, cilt.56, sa.2, ss.220-225, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s11094-022-02624-z
  • Dergi Adı: Pharmaceutical Chemistry Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE
  • Sayfa Sayıları: ss.220-225
  • Anahtar Kelimeler: membrane stabilizing activity, antioxidant, pyrazoline, hydrazone, OXIDATIVE STRESS
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2022, Springer Science+Business Media, LLC, part of Springer Nature.Membrane-stabilizing and antioxidant activities of twenty six pyrazoline and hydrazone derivatives were investigated. Antioxidant activity of these compounds was examined by using in vitro 2,2-azino-bis(3-ethyl-benzothiazoline-6-sulphonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assays. Butylated hydroxytoluene (BHT) was used as DPPH• free radical scavenger standard, and trolox was used as ABTS•+ free radical scavenger standard. Some compounds (D13, D16 and D22) showed good antioxidant activity. All compounds were found to exhibit better membrane stabilizing activity than the reference acetylsalicylic acid.