Synthesis and biological activity of some new lavonylazole derivatives

Evranos B., ALTANLAR N., Ertan R.

Acta Pharmaceutica Sciencia, cilt.49, sa.3, ss.231-238, 2007 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 3
  • Basım Tarihi: 2007
  • Dergi Adı: Acta Pharmaceutica Sciencia
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.231-238
  • Anahtar Kelimeler: Antifungal activities, Antimicrobial, Azoles, Flavone derivatives
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, a new series of 2-[4′-[1-Azolyl]methyl]phenyl]-4H- benzopyran-4-on(A1-A3,A8) and 2-[3′-[1-Azolyl]methyl]phenyl]-4H- benzopyran-4-on (A4-A7) were synthesized by the reaction of 3′- and 4′-bromomethylflavone with azoles in strong alkaline conditions and some physico-chemical properties are described. The chemical structures of all synthesized compounds have been elucidated by IR, 1H-NMR, mass spectra. Antifungal and antibacterial activities of the compounds were compared with Miconazole and Ampicilline trihydrate.