Wound healing effects of methanol extract of Laurocerasus officinalis roem

Ayla S., Okur M. E., Gunal M. Y., Ozdemir E. M., Polat D., Yoltas A., ...Daha Fazla

Biotechnic and Histochemistry, cilt.94, sa.3, ss.180-188, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 94 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/10520295.2018.1539242
  • Dergi Adı: Biotechnic and Histochemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.180-188
  • Anahtar Kelimeler: Antimicrobial, antioxidant, extract, Laurocerasus officinalis, mice, wound healing, ESSENTIAL OIL, ANGIOGENESIS, CHERRY, INFECTIONS
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2018, © 2018 The Biological Stain Commission.Laurocerasus officinalis Roem. (syn: Prunus laurocerasus L.) is a member of Rosaceae family. We investigated the antimicrobial and antioxidant activity of L. officinalis Roem in wound healing both in vivo and in vitro using an excisional wound model model in mice. We used four groups of eight mice as follows: untreated (control), empty gel, extract + gel (L. officinalis + gel), and Madecassol® groups. All treatments were applied topically once daily. The scar area, percentage wound closure and epithelization time were measured. L. officinalis promoted wound healing and increased granulation tissue, epidermal regeneration and angiogenesis. L. officinalis extract, which is known for its antioxidant and antimicrobial activities, may be useful for promoting wound healing.