Akademik Veri Yönetim Sistemi
BIOORGANIC & MEDICINAL CHEMISTRY, cilt.17, sa.18, ss.6583-6589, 2009 (SCI-Expanded)
An efficient synthesis of 5,10-dihydroindeno[1,2-b]indoles (3a-t) containing substituents such as methoxy, hydroxyl, and halogen (F, Cl, and Br) on indeno part was described. Antioxidant and radical scavenging activities of synthesized compounds (3a-t) were determined by various in vitro assays such as 1,1-diphenyl-2-picryl-hydrazyl free radicals (DPPH center dot), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid radicals (ABTS(center dot+)), N,N-dimethyl-p-phenylenediamine dihydrochloride radicals (DMPD center dot+), and superoxide anion radicals (O-2(center dot-)) scavenging, reducing ability determination by the Fe3+-Fe2+ and Cu2+-Cu+ (CUPRAC method) transformation methods, H2O2 scavenging, and ferrous ion (Fe2+) chelating activities. Moreover, these activities were compared to synthetic and standard antioxidants such as butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), alpha-tocopherol, and trolox. The results showed that the synthesized compounds (3a-t) had effective antioxidant power. (C) 2009 Elsevier Ltd. All rights reserved.