Evaluation of anti-inflammatory and antinociceptive activities of helichrysum gaertner species (Asteraceae)

Küpeli E., Tosun A., Bahadir Ö.

Turkish Journal of Pharmaceutical Sciences, cilt.3, sa.3, ss.141-149, 2006 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 3
  • Basım Tarihi: 2006
  • Dergi Adı: Turkish Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.141-149
  • Anahtar Kelimeler: Anti-inflammatory activity, Antinociceptive activity, Asteraceae, H. Arenarium (L.) Moench. subsp. aucheri (Boiss.) Davis & Kupicha, H. noeanum Boiss., H. pilicatum DC. subsp. pilicatum
  • Ankara Üniversitesi Adresli: Evet

Özet

The aqueous extracts obtained from three Helichrysum species (Asteraceae) growing in Turkey, H. arenarium (L.) Moench. subsp. aucheri (Boiss.) Davis & Kupicha, H. noeanum Boiss. and H. pilicatum DC. subsp. pilicatum, were evaluated for their in vivo anti-inflammatory activity using carrageenan-induced hind paw edema and antinociceptive activity using p-benzoquinone-induced abdominal constriction test. Aqueous extracts from H. arenarium and H. pilicatum subsp. pilicatum showed 37.0 %, 30.4 % inhibition at 100 mg/kg doses and 31.2%, 28.3% at 200 mg/kg doses in p-benzoquinone-induced abdominal constriction test, respectively, without inducing any gastric damage. The aqueous extracts of all the plants didn't show any anti-inflammatory activity in carrageenan-induced hind paw edema model at 50, 100 and 200 mg/kg doses. During the acute toxicity evaluation, neither death nor gastric bleeding was observed for any of the plant extracts.