Plasminogen activator inhibitor-1 (PAI-1) gene polymorphism (-675 4G/5G) associated with obesity and vascular risk in children

BERBEROĞLU, MERİH; EVLİYAOĞLU, Saadet; Adiyaman, P.; Ocal, G.; ULUKOL, BETÜL; Simsek, FİLİZ; ŞIKLAR, ZEYNEP; Torel, A.; ÖZEL DEMİRALP, FATMA; Akar, N.

Plasminogen activator inhibitor-1 (PAI-1) gene polymorphism (-675 4G/5G) associated with obesity and vascular risk in children

BERBEROĞLU M., EVLİYAOĞLU S. O., Adiyaman P., Ocal G., ULUKOL B., Simsek F., ...Daha Fazla

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, cilt.19, sa.5, ss.741-748, 2006 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 19 Sayı: 5
Basım Tarihi: 2006
Dergi Adı: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.741-748
Anahtar Kelimeler: PAI-1 gene polymorphism, childhood obesity, vascular disease, INSULIN-RESISTANCE, OVERWEIGHT PREVALENCE, ADOLESCENTS, MORTALITY, TRENDS
Ankara Üniversitesi Adresli: Evet

Özet

Atherothrombotic complications in insulin resistance are partly attributed to impaired fibrinolysis caused by increased PAI-1 plasma levels, and 4G/5G promotor polymorphism of the PAI-1 gene may modulate PAI-1 transcription.