Turkish Journal of Cancer, cilt.36, sa.1, ss.19-22, 2006 (Scopus)
Proteins are susceptible to free radical damage. We measured advanced oxidation protein products (AOPP), selenium and vitamin E levels in serum after whole body irradiation in doses of 8 Gy and 15 Gy in guinea pigs. After 24 hours from irradiation, the serum AOPP levels were increased significantly at 15 Gy dose with respect to the control levels (p<0.05). In both of the irradiated groups, Vitamin E and selenium levels did not change (p>0.05) in serum with respect to the control group, after 24 hours from irradiation. We found that gamma-irradiation caused dose dependent effect on AOPP levels. This result may be related to the fact that a high dose of ionizing irradiation cause excessive oxidative stress while antioxidants such as vitamin E and selenium were not affected after 24 hours from irradiation.