Serum AOPP, selenium and vitamin E levels after irradiation

Güney Y., Türkçü Ü. Ö., Mertoǧlu Ö., Bilgihan A., Hiçsönmez A., Andrieu M. N., ...Daha Fazla

Turkish Journal of Cancer, cilt.36, sa.1, ss.19-22, 2006 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 1
  • Basım Tarihi: 2006
  • Dergi Adı: Turkish Journal of Cancer
  • Derginin Tarandığı İndeksler: Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.19-22
  • Anahtar Kelimeler: Advanced oxidation protein products (AOPP), Ionizing irradiation, Selenium, Vitamin E
  • Ankara Üniversitesi Adresli: Evet

Özet

Proteins are susceptible to free radical damage. We measured advanced oxidation protein products (AOPP), selenium and vitamin E levels in serum after whole body irradiation in doses of 8 Gy and 15 Gy in guinea pigs. After 24 hours from irradiation, the serum AOPP levels were increased significantly at 15 Gy dose with respect to the control levels (p<0.05). In both of the irradiated groups, Vitamin E and selenium levels did not change (p>0.05) in serum with respect to the control group, after 24 hours from irradiation. We found that gamma-irradiation caused dose dependent effect on AOPP levels. This result may be related to the fact that a high dose of ionizing irradiation cause excessive oxidative stress while antioxidants such as vitamin E and selenium were not affected after 24 hours from irradiation.