Vascular reactivity in the experimental, simvastatin-treated diabetes with endothelial dysfunction

Yalcin S., Koksoy C., Ergul E., Demirel E., Yalcin B.

Bratislava Medical Journal, cilt.109, sa.11, ss.477-482, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 109 Sayı: 11
  • Basım Tarihi: 2008
  • Dergi Adı: Bratislava Medical Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.477-482
  • Anahtar Kelimeler: dislipidemia, simvastatin, streptozotocin-diabetes, thapsigargin, vascular reactivity, DEPENDENT VASODILATION, SMOOTH-MUSCLE, CONTRACTILE, THERAPY
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: The aim of this study was to evaluate the effect of simvastatin therapy on genera characteristics of diabetes and vascular reactivity in the 14 week-old streptozotosin-diabetic rats Methods: Twenty-four Sprague-Dawley male rats were divided into four groups as following: control, control-statin, diabetes and diabetes-statin. Results: We observed that hyperglycemia and weight-loss observed in diabetic rats were partially treated with simvastatin, but were still different from the control group. After thapsigargin, the endothel-mediated acetylcholine releasing responses were decreased; the releasing response in diabetes-statin group differed from the diabetic group. Discussion: Simvastatin treatment in diabetic rats, in addition to the treatment of diabetic dislipidemia, has also partially treated the endothel-mediated releasing response in diabetes. We observed that thapsigargin reduces the response of the aortic rings to the current substance.