Evaluation of deleted in malignant brain tumors 1 (DMBT1) gene expression in bladder carcinoma cases: preliminary study

DODURGA Y., BİRAY AVCI Ç., Yilmaz S., Dogan Z. O., Kesen Z., Tataroglu C., ...Daha Fazla

BIOMARKERS, cilt.16, sa.7, ss.610-615, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 7
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/1354750x.2011.620627
  • Dergi Adı: BIOMARKERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.610-615
  • Anahtar Kelimeler: Bladder cancer, DMBT1 gene, gene expression, real-time online RT-PCR, SUPPRESSOR GENES, CANCER, PTEN
  • Ankara Üniversitesi Adresli: Hayır

Özet

This study was undertaken to evaluate the expression of DMBT1 in bladder cancer and its correlation with clinicopathological parameters analyzed in bladder carcinoma patients. We investigated DMBT1 in 56 paraffin embedded specimens of transitional cell carcinoma of the urinary bladder. We assessed DMBT1 gene expression at mRNA level by RT-PCR. Our results show 100% expression of DMBT1 in bladder carcinoma samples. Due to this preliminary results; gene expression was compared to tumor grade, and a significant difference was detected between grade 1 and 3 (p = 0.028). The down-regulation of DMBT1 gene expression in carcinomas suggests the possible role in bladder cancer.