Research Information System
Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.34, no.4, pp.231-249, 2005 (Scopus)
A series of 3-(substituted-benylidene)-1,3-dihydroindole-2-one, 3-(substituted-benylidene)-1,3-dihydroindole 2-thione and bisthio 3-(substituted-benylidene)-1,3-dihydroindole derivatives were investigated as inhibitor of p56Lck by performing receptor docking studies. Some compounds were shown to be docked at the site, where the selective inhibitor PP1 [1-tert-Butyl-3-p-tolyl-1H-pyrazolo[3, 4-d]pyrimidine-4-yl-amine] was embedded at the p56Lck. Evaluation of all compounds for active site interactions with lowest binding energy level, capability of hydrogen bond formation and superimposibility on enzyme active site by docking studies, it was concluded that 3-(substituted-benzylidene)-1,3-dihydroindol-2-thione derivatives would have good interaction with enzyme active site and have more biological activity.