Akademik Veri Yönetim Sistemi
21. Ulusal Hipertansiyon ve Kardiyovasküler Hastalıklar Kongresi, İzmir, Türkiye, 5 - 07 Mayıs 2023, ss.48-49, (Özet Bildiri)
PURPOSE: It is known that left ventricular diastolic dysfunction (LVDD), which is the precursor of many cardiovascular diseases, is associated with an unfavorable prognosis. Today, the incidence of LVDD has also increased as a result of global aging with the increase in medical care. The common feature of conditions such as hypertension, diabetes mellitus, chronic kidney disease, coronary artery disease and chronic lung disease that can lead to LVDD is that they have an inflammatory substrate. It has been reported that many inflammatory parameters are increased in LVDD regardless of the underlying cause. The relationship between systemic immune inflammatory index (SII), a new easily calculated parameter (PlataletxLymphocyte/Neutrophil), which has recently been shown to have prognostic value in cardiovascular diseases, and LVDD is unknown. This study aimed to examine the relationship between LII and LVDD in patients with grade 1 esential hypertension (HT). Material and
METHODS: The study included 117 patients with stage 1 HT (Female/Male: 25/92) without previous heart failure, coronary artery disease, significant valve pathology, pulmonary hypertension and active infection. To rule out age-related grade 1 diastolic dysfunction, patients below 60 years of age were included in the study. The patients were divided into two groups as patients with and without LVDD according to the criteria determined by the guidelines with 2D echocardiography.
RESULTS: The group with LVDD was older, the diabetes mellitus rate and platelet count were higher, and the LDL level was lower than the group without LVDD. SII was found to be statistically higher in the group with LVDD compared to the group without (Table 1). In multivariate logistic regression analysis; Low LDL, advanced age, high platelet and high SII were found to be independently associated with the presence of LVDD (Table 2). In addition, the AUC of 0.672 for SII in the ROC analysis indicates that SII is strongly associated with LVDD (Table 3).
CONCLUSION: Our data demonstrated a positive and independent association with the presence of SII, LVDD in a selected group of patients. Studies have shown that patients with chronic hypertension increased plasma levels of CD14, IL-6, and TNF-α are associated with impaired left atrial function and left ventricular diastolic dysfunction. The systemic proinflammatory state causes coronary microvascular endothelial inflammation, which decreases nitric oxide bioavailability, cyclic guanosine monophosphate content, and protein kinase G activity in adjacent cardiomyocytes, promoting the development of hypertrophy and increasing resting tension.