Akademik Veri Yönetim Sistemi
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.38, sa.4, ss.331-344, 2009 (Scopus)
The purpose of this study was to evaluate the flow properties and compressibilities of different direct tableting agents (DTA) by using pyridoxine hydrochloride as a model drug. Avicel PH 102®, Tablettose 100®, StarLac® and Ludipress® were used as DTAs. Flow rate, angle of repose, bulk and tapped densities of DTAs, binary mixture of drug and DTA and mixtures of drug-DTA-magnesium stearate were examined. Carr's index and Hausner index were calculated to determine the consolidation character of powder mixtures. Tablets were compressed at different pressure by a manual hydraulic press. Heckel and Kawakita equations were fitted to the data obtained from compressibility studies. StarLac® and Ludipress® showed good flow properties as indicated by the lowest angle of repose and the highest flow rate. The Hausner and Carr's index values of these agents were in the range of good flow characteristic values according to the pharmacopoeial limits. The lowest Py values of powder mixture prepared with StarLac® or Ludipress® were also pointed out of acceptable compressibility. When Tablettose® was used in the formulation, capping and lamination problems were occurred at the higher compression pressure. The effect of the increased percent amount of drug (12% to 36%) on the consolidation properties and compressibility was also determined at the formulations prepared with Ludipress®. Optimum consolidation and compressibility characters were obtained by 18% drug while more than 24% drug amount was caused to decreased volume reduction.