Synthesis and Antimicrobial Activity of Some Novel 2-[4-(Substituted Piperazin-/Piperidin-1-ylcarbonyl)phenyl]-1H-benzimidazole Derivatives

KUŞ C., Soezuedoenmez F., ALTANLAR N.

ARCHIV DER PHARMAZIE, vol.342, no.1, pp.54-60, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 342 Issue: 1
  • Publication Date: 2009
  • Doi Number: 10.1002/ardp.200800084
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.54-60
  • Keywords: Antibacterial activity, Antifungal activity, Benzimidazole, Synthesis, BENZIMIDAZOLES
  • Ankara University Affiliated: Yes

Abstract

In this study, we report the synthesis and antimicrobial evaluation of several new 4-(1H-benzimidazol-2-yl)benzamides (11-30) and 5-chloro-1-(p-fluorobenzyl)-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-1H-benzimidazole (33). Compound 20 exhibited the best antibacterial activity with MIC value of 6.25 mu g/mL against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). Significant antifungal activities were obtained with the compounds 13, 14, 18, 19, and 33 with MIC values of 3.12 mu g/mL which are close to fluconazole.