Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Pediatri, cilt.25, sa.2, ss.82-88, 2016 (Scopus)
© Copyright 2016 by Türkiye Klinikleri.Objective: Transforming growth factor-beta (TGF-ß) seems to play an important role in the pathogenesis of hematological malignancies. The aim of this study was to evaluate the importance of serum levels of TGF-ß1 in children with acute leukemia and malignant lymphoma at diagnosis and in remission. Material and Methods: The serum levels of TGF-ß1 were studied by ELISA in 12 children with acute leukemia and 16 children with malignant lymphoma who were diagnosed and treated at Ankara University Faculty of Medicine, Division of Pediatric Oncology between January 2006 and December 2010. Results were compared with 20 healthy controls. Results: In acute leukemia group, the mean level of TGF-ß1 at diagnosis (8.067±3.820 pg/mL) was significantly lower compared with patients in remission (17.663±9.547 pg/mL) and control group (21.565±7.910 pg/mL) (p=0.015 and p<0.001, respectively). There were no relations between serum TGF-ß1 levels and white blood cell count, hemoglobin level, platelet count, and lactate dehydrogenase level in acute leukemia patients. In Hodgkin's lymphoma group, the mean level of TGF-ß1 at diagnosis (19.015±4.035 pg/mL) was lower than in remission (22.942±6.805 pg/mL). The mean level of TGF-ß1 at diagnosis (17.937±7.167 pg/mL) was higher compared to remission (16.055±7.435 pg/mL) in non-Hodgkin's lymphoma group. There were no significant differences between serum levels of TGF-ß1 at diagnosis and in remission in Hodgkin's lymphoma and non-Hodgkin's lymphoma patients (p=0.173 and 0.779, respectively). There were no relations between serum TGF-ß1 levels and erythrocyte sedimentation rate and lactate dehydrogenase level in malignant lymphoma patients. Conclusion: In acute leukemia group, serum level of TGF-ß1 at diagnosis was significantly lower compared with patients in remission and control group TGF-ß1 might be a useful parameter in monitoring the treatment of childhood acute leukemias.