A study on the antioxidant activities of some new benzazole derivatives

ARPACI Ö., Coban T., Tekiner-Gulbas B., Can-Eke B., YILDIZ İ., Aki-Sener E., ...Daha Fazla

ACTA BIOLOGICA HUNGARICA, cilt.57, sa.2, ss.201-209, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1556/abiol.57.2006.2.7
  • Dergi Adı: ACTA BIOLOGICA HUNGARICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.201-209
  • Anahtar Kelimeler: antioxidant activity, benzazole derivatives, superoxide dismutase, lipid peroxidation, DPPH, LIPID PEROXIDE FORMATION, GUINEA-PIG, IN-VITRO, MECHANISMS, ENZYMES, SYSTEM, KIDNEY, LIVER
  • Ankara Üniversitesi Adresli: Evet

Özet

The in vitro antioxidant properties of some new benzazole derivatives (1-10) such as benzoxazoles, benzimidazoles, and benzothiazoles were determined by their effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) level, the scavenging of superoxide anion and the stable radical 2,2diphenyl-1-picrylhydrazyl (DPPH). Compounds 1, 2, 4 and 6, showed potent scavenging effect on superoxide radical at 10(-3) M. Compound 8, 5-nitro-2-(phenoxymethyl) benzimidazole, strongly inhibited lipid peroxidation at 10(-3) M concentration.