A study on the antioxidant activities of some new benzazole derivatives
ACTA BIOLOGICA HUNGARICA, cilt.57, sa.2, ss.201-209, 2006 (SCI-Expanded)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 57 Sayı: 2
- Basım Tarihi: 2006
- Doi Numarası: 10.1556/abiol.57.2006.2.7
- Dergi Adı: ACTA BIOLOGICA HUNGARICA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
- Sayfa Sayıları: ss.201-209
- Anahtar Kelimeler: antioxidant activity, benzazole derivatives, superoxide dismutase, lipid peroxidation, DPPH, LIPID PEROXIDE FORMATION, GUINEA-PIG, IN-VITRO, MECHANISMS, ENZYMES, SYSTEM, KIDNEY, LIVER
- Ankara Üniversitesi Adresli: Evet
Özet
The in vitro antioxidant properties of some new benzazole derivatives (1-10) such as benzoxazoles, benzimidazoles, and benzothiazoles were determined by their effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) level, the scavenging of superoxide anion and the stable radical 2,2diphenyl-1-picrylhydrazyl (DPPH). Compounds 1, 2, 4 and 6, showed potent scavenging effect on superoxide radical at 10(-3) M. Compound 8, 5-nitro-2-(phenoxymethyl) benzimidazole, strongly inhibited lipid peroxidation at 10(-3) M concentration.